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KMID : 0880220110490061050
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Journal of Microbiology
2011 Volume.49 No. 6 p.1050 ~ p.1053
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IL-10 suppresses bactericidal response of macrophages against Salmonella Typhimurium
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Lee Kyoung-Sun
Jeong Eui-Suk
Heo Seung-Ho
Seo Jin-Hee
Jeong Dong-Gu
Choi Yang-Kyu
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Abstract
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We report, herein, an attempt to determine whether an IL-10-induced immunological state affects the response of macrophages against Salmonella Typhimurium (ST). Pretreatment with mrIL-10 induced the intracellular invasion of ST into macrophages in a dose-dependent manner. It also activated AKT phosphorylation, cyclin D1, Bcl-XL, and COX-2 upon ST infection, which may correlate with Salmonella’s survival within the macrophages. However, I-κB phosphorylation was shown to be inhibited, along with the expression of TNF-α and MIP-2α mRNA. Therefore, IL-10 not only suppresses the bactericidal response of macrophages against ST, but also ultimately causes infected macrophages to function as hosts for ST replication.
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KEYWORD
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IL-10, macrophage, Salmonella
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